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We were having an issue opening Excel files from SharePoint 2010 document libraries.  After review their Sharepoint site, we discovered the odd behaviors:

Clicking on a document library link to an Excel document resulted in the following error and also error was occuring for the entire site collection:

Solution:Issue can be fixed by simply activating the “Open Documents in Client Applications by Default” feature in the site collection features (Configures links to documents so they open in client applications instead of Web applications, by default)

Run command IISRESET and you will now be presented with the tried and true standard “Open Document” dialog